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Electric Stimulation on Human Cortex Suppresses Fast Cortical Activity and Epileptic Spikes
Author(s) -
Kinoshita Masako,
Ikeda Akio,
Matsumoto Riki,
Begum Tahamina,
Usui Keiko,
Yamamoto Junichi,
Matsuhashi Masao,
Takayama Motohiro,
Mikuni Nobuhiro,
Takahashi Jun,
Miyamoto Susumu,
Shibasaki Hiroshi
Publication year - 2004
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.0013-9580.2004.60203.x
Subject(s) - stimulation , ictal , epilepsy , neuroscience , cortex (anatomy) , electrocorticography , electroencephalography , cerebral cortex , psychology , human brain , electric stimulation , medicine
Summary: Purpose: To investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans. Methods: A patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50‐Hz alternating square pulse of 0.3‐ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low‐frequency stimulation of 0.9 Hz applied for 15 min. Results: Interictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50‐Hz stimulation. Conclusions: These data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms.