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Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy
Author(s) -
Manganotti Paolo,
Tamburin Stefano,
Bongiovanni Luigi Giuseppe,
Zanette Giampietro,
Fiaschi Antonio
Publication year - 2004
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.0013-9580.2004.21003.x
Subject(s) - juvenile myoclonic epilepsy , transcranial magnetic stimulation , myoclonus , neuroscience , somatosensory system , progressive myoclonus epilepsy , somatosensory evoked potential , stimulation , myoclonic jerk , psychology , motor cortex , epilepsy , medicine
Summary: Purpose: To document whether the mechanisms responsible for myoclonic jerks in juvenile myoclonic epilepsy (JME) are similar to those causing other forms of myoclonus. Methods: We studied somatosensory evoked potentials, the conditioning effect of cutaneous afferents on motor potentials evoked by transcranial magnetic stimulation (TMS), and intracortical inhibition and facilitation in response to paired TMS in a group of nine patients with JME and 20 normal controls. Results: Intracortical inhibition was abnormal, whereas cortical somatosensory evoked potentials and TMS conditioned by cutaneous afferents were unaltered in JME patients. Conclusions: Abnormal processing of cutaneous afferents would not appear to contribute to myoclonus in JME.