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1 H and 31 P Spectroscopic Imaging of Epilepsy: Spectroscopic and Histologic Correlations
Author(s) -
Hetherington Hoby P.,
Kim Jung H.,
Pan Jullie W.,
Spencer Dennis D.
Publication year - 2004
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.0013-9580.2004.04004.x
Subject(s) - epilepsy , interpretation (philosophy) , neuroscience , correlative , medicine , nuclear medicine , nuclear magnetic resonance , pathology , psychology , physics , computer science , philosophy , programming language , linguistics
Summary: Although MRS measurements are useful in assessing the biochemical alterations underlying human epilepsy, to date their use has been limited primarily by three factors: (a) the lack of widespread methods and appropriate hardware for acquiring high‐resolution spectroscopic imaging data, (b) difficulties in spectral interpretation associated with metabolic heterogeneity, and (c) difficulties in biological interpretation due to a lack of correlative histologic studies. In this work, we (a) describe approaches to overcome these hurdles, and (b) discuss the biological interpretation of the spectroscopic findings in TLE.