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Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches
Author(s) -
Müller HansHelge,
Schäfer Helmut
Publication year - 2001
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.2001.00886.x
Subject(s) - interim , adaptive design , group (periodic table) , sequential analysis , computer science , interim analysis , adaptive strategies , mathematical optimization , clinical trial , mathematics , statistics , medicine , chemistry , archaeology , organic chemistry , pathology , history
Summary. A general method is presented integrating the concept of adaptive interim analyses into classical group sequential testing. This allows the researcher to represent every group sequential plan as an adaptive trial design and to make design changes during the course of the trial after every interim analysis in the same way as with adaptive designs. The concept of adaptive trial designing is thereby generalized to a large variety of possible sequential plans.