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Quality‐Adjusted Survival Estimation with Periodic Observations
Author(s) -
Chen PaiLien,
Sen Pranab K.
Publication year - 2001
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.2001.00868.x
Subject(s) - estimator , statistics , disjoint sets , mathematics , survival analysis , variance (accounting) , set (abstract data type) , quality (philosophy) , econometrics , computer science , philosophy , accounting , epistemology , combinatorics , business , programming language
Summary. Quality‐adjusted survival is a measure that integrates both longevity and quality‐of‐life information. The analysis of quality‐adjusted survival in a clinical study with data collected at periodic intervals encounters difficulties due to incomplete information. Based on observed time points, the time axis is partitioned into a set of disjoint time intervals, and under a Markovian assumption on patient's health status, the expected quality‐adjusted survival is estimated as the summed product of the quality of life and its mean sojourn time of each health state within partitioned intervals. It is shown that the estimator is asymptotically normal with a simple variance calculation. A simulation study is conducted to investigate the behavior of the estimator, and a stroke study illustrates the use of the estimator.