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Omnibus Tests for Comparison of Competing Risks with Adjustment for Covariate Effects
Author(s) -
McKeague Ian W.,
Gilbert Peter B.,
Kanki Phyllis J.
Publication year - 2001
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.2001.00818.x
Subject(s) - covariate , statistics , cumulative incidence , confidence interval , hazard ratio , mathematics , proportional hazards model , hazard , econometrics , cohort , biology , ecology
Summary. This article develops omnibus tests for comparing cause‐specific hazard rates and cumulative incidence functions at specified covariate levels. Confidence bands for the difference and the ratio of two conditional cumulative incidence functions are also constructed. The omnibus test is formulated in terms of a test process given by a weighted difference of estimates of cumulative cause‐specific hazard rates under Cox proportional hazards models. A simulation procedure is devised for sampling from the null distribution of the test process, leading to graphical and numerical techniques for detecting significant differences in the risks. The approach is applied to a cohort study of type‐specific HIV infection rates.