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Adaptive Sample Size Calculations in Group Sequential Trials
Author(s) -
Lehmacher Walter,
Wassmer Gernot
Publication year - 1999
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.1999.01286.x
Subject(s) - sample size determination , type i and type ii errors , range (aeronautics) , group (periodic table) , computer science , sample (material) , statistics , sequential estimation , mathematics , algorithm , inverse , sequential analysis , chromatography , materials science , chemistry , geometry , organic chemistry , composite material
Summary. A method for group sequential trials that is based on the inverse normal method for combining the results of the separate stages is proposed. Without exaggerating the Type I error rate, this method enables data‐driven sample size reassessments during the course of the study. It uses the stopping boundaries of the classical group sequential tests. Furthermore, exact test procedures may be derived for a wide range of applications. The procedure is compared with the classical designs in terms of power and expected sample size.