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The Variance for the Disequilibrium Coefficient in the Individual Hardy–Weinberg Test
Author(s) -
Chen John J.,
Thomson GlenysM
Publication year - 1999
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.1999.01269.x
Subject(s) - disequilibrium , hardy–weinberg principle , statistics , mathematics , variance (accounting) , linkage disequilibrium , null hypothesis , biometrics , econometrics , genetics , biology , medicine , allele frequency , computer science , artificial intelligence , allele , economics , accounting , gene , ophthalmology , haplotype
Summary. It is of interest to detect the deviation from Hardy–Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45 , 53–70) suggested a disequilibrium coefficient approach and proposed a 1‐d.f. 2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.