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Nonparametric Identification of the Minimum Effective Dose
Author(s) -
Chen YuhIng
Publication year - 1999
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.0006-341x.1999.01236.x
Subject(s) - nonparametric statistics , identification (biology) , statistics , computer science , econometrics , mathematics , biology , botany
Summary. We consider identifying the minimum effective dose (MED) in a dose‐response study, where the MED is denned to be the lowest dose level producing an effect over that of the zero‐dose control. Proposed herein is a nonparametric procedure based on the Mann–Whitney statistic incorporated with the step‐down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonparametric procedure. Finally, the comparative results of a Monte Carlo level and power study for small sample sizes are presented and discussed.