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Late antenatal carriage of group B Streptococcus by New Zealand women
Author(s) -
Grimwood Keith,
Stone Peter R,
Gosling Isobelle A,
Green Robyn,
Darlow Brian A,
Len Diana R,
Martin Diana R
Publication year - 2002
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.0004-8666.2002.00182.x
Subject(s) - carriage , clindamycin , erythromycin , serotype , group b , medicine , penicillin , streptococcus , risk factor , pregnancy , obstetrics , antibiotics , pediatrics , microbiology and biotechnology , biology , immunology , genetics , pathology , bacteria
Objectives To determine in New Zealand women the prevalence of group B Streptococcus (GBS) carriage late in pregnancy and to identify GBS colonisation risk factors, antibiotic susceptibility and serotype distribution. Design Prospective, observational study. Setting Community and hospital antenatal clinics in Wellington and Auckland during 1998–1999. Sample Convenience sample of 240 women between 35–37 weeks gestation. Methods Sociodemographic data, obstetric details and anogenital swabs were collected from each subject. Swabs were inoculated into selective media. GBS isolates underwent serotyping and antibiotic susceptibility testing. Results Two hundred and forty women (9% Maori, 11% Pacific) aged 15–41 years were recruited. Fifty‐two (22%; 95% CI 17, 27) were colonised by GBS. Carriage was independently associated with younger age (59%≤ 30 years; adjusted OR 3.25; 95% CI 1.53, 6.95) and least social deprivation (57% NZ Dep 96 score ≤ 3; adjusted OR 1.22; 95% CI 1.06, 1.39). All GBS isolates were penicillin‐susceptible, but resistance to clindamycin (15%) and erythromycin (7.5%) was detected and associated with serotype V strains. Predominant serotypes were: III (29%), Ia (21%), Ib (20%) and V (20%). Conclusions Approximately 20% of New Zealand women carry GBS late in pregnancy, with young age a major risk factor. Increased risk in the socially advantaged, development of resistance to erythromycin and clindamycin, and emergence of new GBS serotypes are findings with important implications for prevention strategies requiring further confirmation.