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Prothrombin G20210A mutation is not associated with recurrent miscarriages
Author(s) -
Chua Boon Ghee,
Burrows Robert F
Publication year - 2002
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.0004-8666.2002.00167.x
Subject(s) - medicine , odds ratio , abortion , confidence interval , mutation , recurrent miscarriage , prothrombin g20210a , pregnancy , obstetrics , gastroenterology , gynecology , factor v leiden , genetics , thrombosis , venous thrombosis , biology , gene
Objective To assess the association between prothrombin G20210A mutation and recurrent miscarriages. Study design A literature review was performed in Medline identifying articles from 1966 to December 2000. Articles meeting inclusion criteria were systematically reviewed and included in a meta‐analysis. Results Six trials, all case‐controlled, were identified. These trials included 323 women with recurrent pregnancy loss. The odds ratio (OR) for heterozygous prothrombin mutation was 1.9 (95% confidence interval (CI) 0.98–4.14), and for homozygous prothrombin mutation was 3.76 (95% CI 0.75–18.77). The OR for prothrombin mutation and primary recurrent abortion was 2.19 (95% CI 0.61–7.89) and for prothrombin mutation and secondary recurrent abortion was 1.29 (95% CI 0.2–8.36). Conclusion There is no evidence to support an association of prothrombin G20210A mutation with recurrent miscarriages.