Open AccessBiomarkers for the prediction of preterm delivery
Author(s) -
Vogel Ida,
Thorsen Poul,
Curry Allison,
Sandager Puk,
Uldbjerg Niels
Publication year - 2005
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.0001-6349.2005.00771.x
Subject(s) - medicine , fetal fibronectin , bacterial vaginosis , amniotic fluid , cervicitis , relaxin , gastroenterology , ureaplasma urealyticum , preterm delivery , gynecology , endocrinology , hormone , pregnancy , gestation , fetus , mycoplasma , biology , genetics
This structured review discusses the current literature on selected biomarkers and their ability to predict preterm delivery (PTD). Among symptomatic women, the likelihood ratio (LR+) for the prediction of PTD was found to be greater than 10 using amniotic fluid (AF) interleukin‐6 (IL‐6), AF Ureaplasma urealyticum, as well as a multi‐marker consisting of cervical IL‐6, cervical IL‐8, and cervical length (CL). The LR+ was found to be between 5 and 10 for serum C‐reactive protein (CRP). An LR+ between 2.5 and 5 was recorded for serum corticotropin‐releasing hormone (CRH), cervical fetal fibronectin (fFN), cervical IL‐6, serum relaxin, and a multi‐marker consisting of fFN and CL. CL and bacterial vaginosis (BV) both predicted PTD in women with preterm labor with an LR+ of less than 2.5. In asymptomatic women, AF U. urealyticum and a multimarker consisting of five individual markers [fFN, CL, serum alpha‐fetoprotein (AFP), serum alkaline phosphatase, and serum granulocyte colony‐stimulating factor (G‐CSF)] predicted PTD with an LR+ greater than 10 . The LR+ was between 5 and 10 for serum relaxin and CL. LRs+ recorded for serum alkaline phosphatase, salivary estriol, serum CRH, serum G‐CSF, cervical IL‐6, AF IL‐6, cervical fFN, AFP, and Chlamydia all ranged between 2.5 and 5. Finally, an LR+ below 2.5 has been documented for serum ferritin, serum CRP, BV, and cervical ferritin.