Open AccessPlacental imbalance of Th1‐ and Th2‐type cytokines in preeclampsia
Author(s) -
Dong Minyue,
He Jing,
Wang Zhengping,
Xie Xing,
Wang Hanzhi
Publication year - 2005
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.0001-6349.2005.00714.x
Subject(s) - preeclampsia , medicine , gestational hypertension , pregnancy , gestation , endocrinology , cytokine , gestational age , tumor necrosis factor alpha , placenta , pathogenesis , obstetrics , fetus , biology , genetics
Objectives. To characterize the changes in the level of T helper 1 (Th1)‐ [interleukin (IL)‐2 and tumor necrosis factor (TNF)‐α] and Th2‐type cytokine (IL‐10) and the ratios of Th1/Th2 (IL‐2/IL‐10 and TNF‐α/IL‐10) in placentae from women with preeclampsia and women with gestational hypertension. Methods. Placental levels of IL‐2, TNF‐α, and IL‐10 were determined with radioimmunoassay and Th1/Th2 ratios (IL‐2/IL‐10 and TNF‐α/IL‐10) calculated in the placentae from 22 women with preeclampsia, 15 women with gestational hypertension, and 32 normal term pregnant women. Results. Although preeclampsia had the trend of the increase in the placental levels of IL‐2 and TNF‐α and the trend of the decrease in placental IL‐10, there were not significant difference in placental levels of IL‐2, IL‐10, and TNF‐α among preeclampsia, gestational hypertension, and normal pregnancy ( P > 0.05 for all). Placental ratios of IL‐2/IL‐10 and TNF‐α/IL‐10 were significantly higher in preeclampsia than in normal pregnancy ( P = 0.035 and P = 0.005, respectively). No differences of Th1/Th2 ratios were found between preeclampsia and gestational hypertension and between gestational hypertension and normal pregnancy ( P > 0.05 for all). Conclusions. Alterations of placental balances of cytokines with Th1 predominance were demonstrated in preeclampsia. These associations may offer insights into the pathogenesis of preeclampsia.