Open AccessSerum vascular endothelial growth factor 165 levels and uterine fibroid volume
Author(s) -
Chen DaChung,
Liu JahYao,
Wu GwoJang,
Ku ChihHung,
Su HerYoung,
Chen ChiHuang
Publication year - 2005
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.0001-6349.2005.00621.x
Subject(s) - medicine , hysterectomy , uterine fibroids , vascular endothelial growth factor , gynecology , uterine leiomyoma , uterus , vegf receptors , surgery
Background. Vascular endothelial growth factor 165 (VEGF 165 ) demonstrates increased expression in uterine fibroids. This study aimed to investigate the relationship between serum VEGF 165 levels and uterine fibroid volume. Methods. On a prospective observational basis, 80 women with symptomatic uterine fibroids underwent hysterectomy. Uterine weight was determined after hysterectomy. Six hours before and 48 h after hysterectomy, serum VEGF 165 levels were measured using an enzyme‐linked immunosorbent assay. Results. Logistic regression analysis showed no correlation between serum VEGF 165 levels and uterine weight ( r = 0.0037; P > 0.05). The mean serum VEGF 165 level declined significantly from 716.31 ± 457.99 to 581.81 ± 403.32 pg/mL after hysterectomy ( P < 0.0001). Controlling for age, body mass index, uterine weight, proliferative or secretory phase, and parity, only parous patients ( n = 58) were found to have significantly decreased serum VEGF 165 levels after hysterectomy ( P = 0.000035), in contrast to nulliparous patients ( n = 22; P = 0.15). Conclusions. Serum VEGF 165 levels do not correlate with uterine fibroid volume, but demonstrate a significant decrease after hysterectomy. The decrease in serum VEGF 165 levels after hysterectomy was significant in parous but not in nulliparous patients with uterine fibroids. Serum VEGF 165 levels may not predict uterine fibroid development.