Open AccessPathophysiology of coronavirus disease 2019 for wound care professionals
Author(s) -
AlBenna Sammy
Publication year - 2020
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.13483
Subject(s) - medicine , immunology , coronavirus , immune system , complement system , pathophysiology , tropism , innate immune system , chemokine , coagulopathy , pathogenesis , disease , inflammation , tissue tropism , virus , covid-19 , infectious disease (medical specialty) , pathology
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) which causes Coronavirus disease 2019 (COVID‐19). The tissue tropism of SARS‐CoV‐2 includes not only the lung but also the vascular and integumentary systems. Angiotensin‐converting enzyme 2 (ACE2) appears to be the key functional receptor for the virus. There is a prominent innate immune response to SARS‐CoV‐2 infection, including inflammatory cytokines, chemokines, the complement system, and acute phase proteins. The pathophysiologic significance of SARS‐COV‐2 and host immune system interaction, and COVID‐19‐associated coagulopathy instigating microvascular injury syndrome mediated by activation of complement pathways, and an associated procoagulant state is important for wound care professionals to understand.