Open AccessSystematic review of the use of cyanoacrylate glue in addition to standard wound closure in the prevention of surgical site infection
Author(s) -
Machin Matthew,
Liu Chen,
Coupland Alex,
Davies Alun Huw,
Thapar Ankur
Publication year - 2019
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.13044
Subject(s) - medicine , cyanoacrylate , glue , cochrane library , surgery , randomized controlled trial , meta analysis , incidence (geometry) , systematic review , clinical trial , wound closure , medline , wound healing , adhesive , materials science , layer (electronics) , composite material , chemistry , physics , organic chemistry , political science , law , optics
Surgical site infection (SSI) is associated with increased morbidity, length of stay, and cost. Cyanoacrylate glue is a low‐cost, fluid‐proof, antimicrobial barrier. The aim of this systematic review is to assess the use of cyanoacrylate glue after standard wound closure versus dressings in the reduction of SSI. Medline, Embase, Cochrane Library, and clinical trial registries were searched with no restrictions in accordance with PRISMA guidelines. Eligibility criteria were prospective studies comparing glue versus dressings after standardised wound closure. Two reviewers independently screened articles and utilised GRADE for quality assessment. Meta‐analysis was not performed because of the heterogeneity of the data. Three articles were included in the review. Study quality was uniformly low. Incidence of SSI was low, between 0% and 4%. No significant differences were reported in the single randomised controlled trial. A single non‐randomised parallel group trial reported a significant reduction in the incidence of SSI in the cyanoacrylate group. There was no consistent evidence demonstrating reduction in SSI as a result of the use of cyanoacrylate glue. Future studies should assess the use of cyanoacrylate in procedures with a higher rate of SSI, for example, lower limb bypass.