Open AccessEnzymatic debridement with collagenase in wounds and ulcers: a systematic review and meta‐analysis
Author(s) -
Patry Jérôme,
Blanchette Virginie
Publication year - 2017
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12760
Subject(s) - medicine , collagenase , debridement (dental) , meta analysis , adverse effect , medline , wound healing , surgery , cinahl , systematic review , microbial collagenase , randomized controlled trial , intensive care medicine , psychological intervention , enzyme , biochemistry , chemistry , psychiatry , political science , law
Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost‐effectiveness and the occurrence of adverse events. We conducted a systematic literature search on available literature in Cochrane databases, MEDLINE , EMBASE and CINAHL . Two investigators independently assessed the titles and abstracts of all randomised controlled trials obtained involving collagenase of all kinds of wounds based on inclusion criteria. Of the 1411 citations retrieved, 22 studies reported outcomes with the use of collagenase either for wound healing or wound debridement. Results support the use of collagenase for enzymatic debridement in pressure ulcers, diabetic foot ulcers and in conjunction with topical antibiotics for burns. However, studies presented a high risk of bias. Risk ratio of developing an adverse event related to collagenase versus the alternative treatment was statistically significant (for 10 studies, RR : 1·79, 95% CI 1·24–2·59, I 2 =0%, P = 0·002). There is very limited data on the effect of collagenase as an enzymatic debridement technique on wounds. More independant research and adequate reporting of adverse events are warranted.