Non‐healing ischaemic digital ulcer in a systemic sclerosis patient: a challenging clinical case

Ischaemic digital ulcers ( DUs ) are an indicator of the severity of the microangiopathy in patients with systemic sclerosis ( SSc ). DUs are a frequent complication, affecting about 50% of patients with SSc , and are often recurrent. In cross‐sectional studies involving patients with SSc , the frequency of ischaemic DUs was 12–16% with a major impact on hand function and quality of life. Effective therapy for DUs remains elusive. Intravenous iloprost has been demonstrated to have a positive effect on healing of active DUs . Bosentan, an oral endothelin receptor antagonist, only showed a benefit in preventing the occurrence of new DUs . Despite limited evidence, recent guidelines have recommended phosphodiesterase type 5 inhibitors as an option. Injection of botulinum toxin and digital sympathectomy have been increasingly used for ischaemic DUs . Here we present the complex case of a SSc patient already treated with sildenafil and bosentan in whom an active DU was successfully treated with botulinum toxin A. Despite the lack of a randomised controlled trial, results are encouraging for the use of botulinum toxin in the treatment of DUs and could perhaps help to avoid some amputations, as in the present case.