Open AccessHealing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction
Author(s) -
Ojalvo Ariana García,
Acosta Jorge Berlanga,
Marí Yssel Mendoza,
Mayola Maday Fernández,
Pérez Calixto Valdés,
Gutiérrez William Savigne,
Marichal Ileydis Iglesias,
Seijas Eduardo Álvarez,
Kautzman Alicia Molina,
Pacheco Angélica Estrada,
Armstrong David G.
Publication year - 2017
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12592
Subject(s) - medicine , oxidative stress , diabetic foot , diabetic foot ulcer , epidermal growth factor , diabetes mellitus , antioxidant , wound healing , growth factor , pathogenesis , gastroenterology , pathology , surgery , endocrinology , receptor , biochemistry , chemistry
The diabetic foot ulcer ( DFU ) is the leading cause of lower extremity amputation worldwide and is directly associated with comorbidity, disability and mortality. Oxidative stress mechanisms have been implicated in the pathogenesis of these wounds. Intra‐lesional infiltration of epidermal growth factor has emerged as a potential therapeutic alternative to allow for physiological benefit while avoiding the proteolytic environment at the centre of the wound. The aim of this study was to characterise the response of patients with DFUs to epidermal growth factor treatment in terms of redox status markers. Experimental groups included patients with DFUs before and 3–4 weeks after starting treatment with epidermal growth factor; compensated and non‐compensated diabetic patients without ulcers; and age‐matched non‐diabetic subjects. Evaluations comprised serum levels of oxidative stress and antioxidant reserve markers. Patients with DFUs exhibited the most disheveled biochemical profile, with elevated oxidative stress and low antioxidant reserves, with respect to non‐ulcerated diabetic patients and to non‐diabetic subjects. Epidermal growth factor intra‐lesional administration was associated with a significant recovery of oxidative stress and antioxidant reserve markers. Altogether, our results indicate that epidermal growth factor intra‐ulcer therapy contributes to restore systemic redox balance in patients with DFUs .