Open AccessHigh inspired oxygen versus low inspired oxygen for reducing surgical site infection: a meta‐analysis
Author(s) -
Wang Hongye,
Hong Shukun,
Liu Yuanyuan,
Duan Yan,
Yin Hongmei
Publication year - 2017
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12548
Subject(s) - medicine , meta analysis , confidence interval , subgroup analysis , randomized controlled trial , incidence (geometry) , surgical site infection , relative risk , oxygen , surgery , physics , chemistry , organic chemistry , optics
To perform a meta‐analysis of published literature to assess the role of high‐concentration inspired oxygen in reducing the incidence of surgical site infections ( SSIs ) following all types of surgery, a comprehensive search for published randomized controlled trials ( RCTs ) comparing high‐ with low‐concentration inspired oxygen for SSIs was performed. The related data were extracted by two independent authors. The fixed and random effects methods were used to combine data. Twelve RCTs involving 6750 patients were included. Our pooled result found that no significant difference in the incidence of SSIs was observed between the two groups, but there was high statistic heterogeneity across the studies [risk ratio ( RR ): 0·91; 95% confidence interval ( CI ): 0·72–1·14; P = 0·40; I 2 = 54%]. The sensitivity analysis revealed the superiority of high‐concentration oxygen in decreasing the SSI rate (RR: 0·86; 95% CI: 0·75–0·98; P = 0·02). Moreover, a subgroup analysis of studies with intestinal tract surgery showed that patients experienced less SSI when high‐concentration inspired oxygen was administrated (RR: 0·53; 95% CI: 0·37–0·74; P = 0·0003). Our study provided no direct support for high‐concentration inspired oxygen in reducing the incidence of SSIs in patients undergoing all types of surgery.