Open AccessHybrid imaging with 99mTc‐WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis
Author(s) -
Lazaga Francisco,
Van Asten Suzanne AV,
Nichols Adam,
Bhavan Kavita,
La Fontaine Javier,
Oz Orhan K,
Lavery Lawrence A
Publication year - 2016
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12433
Subject(s) - medicine , osteomyelitis , diabetic foot , single photon emission computed tomography , retrospective cohort study , nuclear medicine , radiology , spect imaging , osteitis , diabetes mellitus , surgery , endocrinology
This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis ( DFO ) with Tc‐99m WBC ‐labelled single photon emission computed tomography ( SPECT / CT ) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc‐99m WBC ‐labelled SPECT / CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re‐admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT / CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc‐99m WBC ‐labelled SPECT / CT imaging may be useful to help determine treatment outcomes for DFO.