Open AccessComparison of skin effects of immediate treatment modalities in experimentally induced hydrofluoric acid skin burns
Author(s) -
Songur Meltem K,
Akdemir Ovunc,
Lineaweaver William C,
Cavusoglu Turker,
Ozsarac Murat,
Aktug Huseyin,
Songur Ecmel,
Tiftikcioglu Yigit O
Publication year - 2015
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12214
Subject(s) - medicine , saline , epidermal growth factor , hydrofluoric acid , magnesium , infiltration (hvac) , surgery , gastroenterology , urology , anesthesia , chemistry , physics , receptor , organic chemistry , thermodynamics
Hydrofluoric acid ( HF ) burns cause immediate damage and painful long‐term sequellae. Traditionally, chelating agents have been used as the initial treatment for such burns. We have introduced epidermal growth factor ( EGF ) into an HF model to compare EGF with Ca 2+ and Mg 2+ treatments; 40 Sprague Dawley rats were divided into five groups. Each rat suffered a 6 × 4 cm 2 burn induced by 40% HF . Group 1 had no treatment, group 2 had saline injected beneath the burn, group 3 received magnesium sulphate injections, group 4 received calcium gluconate and group 5 received EGF . Specimens were evaluated via planimetry and biopsy at intervals of 4, 8, 24 and 72 hours. Fluid losses were significantly less in the Mg 2+ and EGF groups. The EGF group had the smallest burn area, least oedema, least polymorphonuclear granulocyte ( PMN ) infiltration, most angiogenesis and highest fibroblast proliferation of any group ( P < 0·005). EGF limited HF damage morphologically and histologically more effectively than Ca 2+ or Mg 2+ . This finding indicates that HF treatment via growth factors may be an improvement over chelation therapy.