Open AccessA case of dominant dystrophic epidermolysis bullosa with diabetes mellitus presenting as progressive recalcitrant blisters and erosions
Author(s) -
Park Kio,
Nakano Hajime,
Sawamura Daisuke,
Kabashima Kenji,
Miyachi Yoshiki
Publication year - 2014
Publication title -
international wound journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 63
eISSN - 1742-481X
pISSN - 1742-4801
DOI - 10.1111/iwj.12046
Subject(s) - blisters , medicine , dermatology , epidermolysis bullosa , anchoring fibrils , skin biopsy , biopsy , bulla (seal) , dermis , dystrophy , pathology , ultrastructure , lung , immunology
Dear Editors, Dominant dystrophic epidermolysis bullosa (DDEB) is a rare inherited blistering disorder resulting from mutations in the COL7A1 gene. This gene encodes type VII collagen, a major component of anchoring fibrils, at the dermal–epidermal junction. Its clinical features include recurrent blisters that primarily occur on the extremities as well as nail dystrophy. Here, we report a case of DDEB presenting as recent progressive recalcitrant blisters, which may be related to the onset of diabetes mellitus. A 71-year-old man was referred to our hospital with recent progressive recalcitrant blisters and erosions. The patient had been suffering from recurrent trauma-induced skin blisters and