Open AccessComparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post‐discharge assessed by Respiratory Intensity and Impact Questionnaire
Author(s) -
Falsey Ann R.,
Walsh Edward E.,
Osborne Richard H.,
Vandendijck Yannick,
Ren Xiaohui,
Witek James,
Kang Diye,
Chan Eric,
Scott Jane,
Ispas Gabriela
Publication year - 2022
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12903
Subject(s) - medicine , human metapneumovirus , asthma , respiratory tract infections , respiratory system , cohort , population , respiratory disease , cohort study , prospective cohort study , lung , environmental health
Background The hospitalized acute respiratory tract infection (HARTI) study used the Respiratory Intensity and Impact Questionnaire (RiiQ™) Symptom Scale, derived from FluiiQ™, to assess and compare the burden of respiratory infection symptoms for patients with influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) infection, with or without core risk factors (CRF) (age ≥65; chronic heart, renal, obstructive pulmonary disease; asthma). Methods This was a prospective cohort study in adult patients hospitalized with acute respiratory tract infection (40 centers, 12 countries) during two consecutive influenza/RSV/hMPV seasons (2017–2019). The RiiQ™ Symptom Scale and EuroQol 5‐Dimensions 5‐Levels (EQ‐5D‐5L) were assessed by interview at two timepoints during hospitalization and at 1, 2, and 3 months post‐discharge. Results Mean lower respiratory tract (LRT) symptom scores were higher for RSV and hMPV participants compared to influenza at 48 h after enrollment/early discharge ( p = 0.001) and 3 months post‐discharge ( p = 0.007). This was driven by LRT symptoms, including shortness of breath (SOB) ( p < 0.01) and wheezing ( p < 0.01) during hospitalization, and SOB ( p < 0.05) and cough ( p < 0.05) post‐discharge. Participants with CRF reported more moderate‐to‐severe SOB ( p < 0.05) and wheezing ( p < 0.05) compared to CRF(−) participants post‐discharge. EQ‐5D‐5L scores were moderately associated with RiiQ™ LRT and systemic symptoms domains. Conclusions Results from the HARTI study suggest that in the study population, LRT symptoms were more severe for RSV and hMPV groups and for patients with CRF. RiiQ™ Symptom Scale scores shows a moderate association with EQ‐5D‐5L indicating that the RiiQ™ may provide useful insights and offer advantages over other measures for use in interventional RSV adult clinical studies.