Open AccessBurden of respiratory viral infection in persons with human immunodeficiency virus
Author(s) -
Sellers Subhashini A.,
Dover Kenton L.,
Bailey Aubrey G.,
Cheves Avery,
Eason Anthony B.,
Popowitch Elena B.,
Miller Melissa B.,
Wohl David A.,
Dittmer Dirk P.,
Fischer William A.
Publication year - 2020
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12734
Subject(s) - respiratory system , medicine , virus , virology , pathogen , metapneumovirus , human immunodeficiency virus (hiv) , immunology , polymerase chain reaction , biology , respiratory tract infections , human metapneumovirus , gene , biochemistry
This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real‐time reverse transcription polymerase chain reaction and primer‐independent next‐generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU admission and 16 (59%) required mechanical ventilation. The proportion of respiratory viruses identified, and the associated complicated hospital course highlights the significant role that RVIs play in the lung health of PLH.