Open AccessInfluenza Classification Suite: An automated Galaxy workflow for rapid influenza sequence analysis
Author(s) -
Eisler Diane,
Fornika Dan,
Tindale Lauren C.,
Chan Tracy,
Sabaiduc Suzana,
Hickman Rebecca,
Chambers Catharine,
Krajden Mel,
Skowronski Danuta M.,
Jassem Agatha,
Hsiao William
Publication year - 2020
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12722
Subject(s) - clade , suite , workflow , computational biology , biology , virology , computer science , influenza a virus subtype h5n1 , genetics , database , gene , virus , phylogenetics , geography , archaeology
Influenza viruses continually evolve to evade population immunity, and the different lineages are assigned into clades based on shared mutations. We have developed a publicly available computational workflow, the Influenza Classification Suite, for rapid clade mapping of sequenced influenza viruses. This suite provides a user‐friendly workflow implemented in Galaxy to automate clade calling and antigenic site extraction. Workflow input includes clade definition and amino acid index array files, which can be customized to identify any clades of interest. The Influenza Classification Suite provides rapid, high‐resolution understanding of circulating influenza strain evolution to inform influenza vaccine effectiveness and the need for potential vaccine reformulation.