Persistence of H7N9 virus antibody response 2 years after infection | Zendy

Yao Lin | Zendy; Wang GuoLin | Zendy; Chen LiLing | Zendy; Liu Cheng | Zendy; Duan LiJun | Zendy; Gray Gregory C. | Zendy; Ma MaiJuan | Zendy

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Persistence of H7N9 virus antibody response 2 years after infection

Author(s) -

Yao Lin,

Wang GuoLin,

Chen LiLing,

Liu Cheng,

Duan LiJun,

Gray Gregory C.,

Ma MaiJuan

Publication year - 2020

Publication title -

influenza and other respiratory viruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.743

H-Index - 57

eISSN - 1750-2659

pISSN - 1750-2640

DOI - 10.1111/irv.12702

Subject(s) - titer , antibody , antibody response , persistence (discontinuity) , hemagglutination assay , antibody titer , virus , medicine , virology , immunology , neuraminidase , geotechnical engineering , engineering

We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016‐September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7‐28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7‐51.2) and 73.45 (54.7‐106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long‐term antibody response at least 2 years after infection.

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