Open AccessPersistence of H7N9 virus antibody response 2 years after infection
Author(s) -
Yao Lin,
Wang GuoLin,
Chen LiLing,
Liu Cheng,
Duan LiJun,
Gray Gregory C.,
Ma MaiJuan
Publication year - 2020
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12702
Subject(s) - titer , antibody , persistence (discontinuity) , antibody response , hemagglutination assay , antibody titer , virus , virology , medicine , immunology , neuraminidase , hemagglutination , biology , geotechnical engineering , engineering
We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016‐September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7‐28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7‐51.2) and 73.45 (54.7‐106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long‐term antibody response at least 2 years after infection.