Open AccessSerological response to influenza vaccination among adults hospitalized with community‐acquired pneumonia
Author(s) -
Pratt Caroline Quinn,
Zhu Yuwei,
Grijalva Carlos G.,
Wunderink Richard G.,
Mark Courtney D.,
Waterer Grant,
Levine Min Z,
Jefferson Stacie,
Self Wesley H.,
Williams Derek J.,
Finelli Lynn,
Bramley Anna M.,
Edwards Kathryn M.,
Jain Seema,
Anderson Evan J.
Publication year - 2019
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12622
Subject(s) - vaccination , serology , medicine , pneumonia , hemagglutination assay , virology , titer , community acquired pneumonia , immunology , antibody titer , orthomyxoviridae , influenza vaccine , influenzavirus b , influenza a virus , antibody , virus
Ninety‐five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction ( PCR ) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers ( HAI ) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty‐six (69%) patients seroconverted (≥4‐fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.