Open AccessBurden and epidemiology of influenza‐ and respiratory syncytial virus‐associated severe acute respiratory illness hospitalization in Madagascar, 2011‐2016
Author(s) -
Rabarison Joelinotahina H.,
Tempia Stefano,
Harimanana Aina,
Guillebaud Julia,
Razanajatovo Norosoa H.,
Ratsitorahina Maherisoa,
Heraud JeanMichel
Publication year - 2019
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12557
Subject(s) - medicine , epidemiology , respiratory system , pediatrics , respiratory illness , population , retrospective cohort study , influenza like illness , virus , virology , environmental health
Background Influenza and respiratory syncytial virus ( RSV ) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza‐ and RSV ‐associated hospitalization are limited in Africa. Methods We conducted hospital‐based surveillance for laboratory‐confirmed influenza‐ and RSV ‐associated severe acute respiratory illness ( SARI ) among patients of any age at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011‐2016. We estimated age‐specific rates (per 100 000 population) of influenza‐ and RSV ‐associated SARI hospitalizations for the Antananarivo region and then extrapolated these rates to the national level. Results Overall, the mean annual national number of influenza‐associated SARI hospitalizations for all age groups was 6609 (95% CI : 5381‐7835‐rate: 30.0; 95% CI : 24.4‐35.6), 4468 (95% CI : 3796‐5102‐rate: 127.6; 95% CI : 108.4‐145.7), 2141 (95% CI : 1585‐2734‐rate: 11.6; 95% CI : 8.6‐14.8), and 339 (95% CI : 224‐459‐rate: 50.0; 95% CI : 36.3‐74.4) among individuals aged <5, ≥5, and ≥65 years, respectively. For these same age groups, the mean annual number of RSV ‐associated SARI hospitalizations was 11 768 (95% CI : 10 553‐12 997‐rate: 53.4; 95% CI : 47.9‐59.0), 11 299 (95% CI : 10 350‐12 214‐rate: 322.7; 95% CI : 295.6‐348.8), 469 (95% CI : 203‐783‐rate: 2.5;95% CI : 1.1‐4.2), and 36 (95% CI : 0‐84‐rate: 5.8; 0.0‐13.5), respectively. Conclusion The burden of influenza‐ and RSV ‐associated SARI hospitalization was high among children aged <5 years. These first estimates for Madagascar will enable government to make informed evidence‐based decisions when allocating scarce resources and planning intervention strategies to limit the impact and spread of these viruses.