Open AccessSpecies‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
Author(s) -
Bouvier Monique,
Chen WeiJu,
Arnold John C.,
Fairchok Mary P.,
Danaher Patrick J.,
Lalani Tahaniyat,
Malone Leslie,
Mor Deepika,
Ridoré Michelande,
Burgess Timothy H.,
Millar Eugene V.
Publication year - 2018
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12538
Subject(s) - influenza like illness , coronavirus , covid-19 , medicine , betacoronavirus , observational study , pandemic , virology , immunology , disease , virus , infectious disease (medical specialty) , outbreak
Human coronavirus (HCoV) is a known cause of influenza‐like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR‐positive for HCoV. The distribution of species was as follows: HCoV‐OC43 (34%), HCoV‐229E (28%), HCoV‐NL63 (22%), and HCoV‐HKU1 (16%). We did not observe species‐specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV‐HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.