Open AccessEstimating vaccine effectiveness in preventing laboratory‐confirmed influenza in outpatient settings in South Africa, 2015
Author(s) -
McAnerney Johanna M.,
Walaza Sibongile,
Tempia Stefano,
Blumberg Lucille,
Treurnicht Florette K.,
Madhi Shabir A.,
ValleyOmar Ziyaad,
Cohen Cheryl
Publication year - 2017
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12436
Subject(s) - influenza vaccine , seasonal influenza , medicine , virology , influenza a virus , influenza season , flu season , virus , outpatient clinic , live attenuated influenza vaccine , vaccine efficacy , vaccination , covid-19 , infectious disease (medical specialty) , disease
Trivalent seasonal influenza vaccine effectiveness during the 2015 season in South Africa was assessed using a test‐negative case control study design. Influenza A(H1N1)pdm09 was the dominant circulating strain. Overall influenza vaccine coverage was 3.2% (29/899). The vaccine effectiveness estimate, against any influenza virus infection, adjusted for age, underlying conditions and timing within season was 46.2% (95% CI: −23.5 to 76.5), and 53.6% (95% CI: −62.6 to 80.3) against influenza A(H1N1)pdm09.