Open AccessAssessment of antigenic difference of equine influenza virus strains by challenge study in horses
Author(s) -
Yamanaka Takashi,
Nemoto Manabu,
Bannai Hiroshi,
Tsujimura Koji,
Kondo Takashi,
Matsumura Tomio,
Gildea Sarah,
Cullinane Ann
Publication year - 2016
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12418
Subject(s) - equine influenza , virology , horse , virus , antigen , antiserum , medicine , influenza vaccine , biology , immunology , paleontology
We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 ( LP 93) exhibited reduced cross‐neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 ( CL 11). As a result, Japanese vaccine manufacturers will replace LP 93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP 93 were challenged by exposure to a nebulized aerosol of CL 11. The durations of pyrexia (≥38.5°C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP 93 group.