Open AccessOseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014–2015 influenza season in Alberta, Canada
Author(s) -
Chaudhry Ahsan,
Bastien Nathalie,
Li Yan,
Scott Allison,
Pabbaraju Kanti,
Stewart Douglas,
Wong Sallene,
Drews Steven J.
Publication year - 2016
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12415
Subject(s) - oseltamivir , zanamivir , neuraminidase , neuraminidase inhibitor , virology , virus , influenza a virus , biology , microbiology and biotechnology , medicine , covid-19 , infectious disease (medical specialty) , disease
This manuscript describes the identification of an oseltamivir‐resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada, during the 2014–2015 influenza season. Following treatment with oseltamivir, neuraminidase ( NA ) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA ‐Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir‐resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient.