Open AccessRapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation)
Author(s) -
Komissarov Andrey,
Fadeev Artem,
Sergeeva Maria,
Petrov Sergey,
Sintsova Kseniya,
Egorova Anna,
Pisareva Maria,
Buzitskaya Zhanna,
Musaeva Tamila,
Danilenko Daria,
Konovalova Nadezhda,
Petrova Polina,
Stolyarov Kirill,
Smorodintseva Elizaveta,
Burtseva Elena,
Krasnoslobodtsev Kirill,
Kirillova Elena,
Karpova Lyudmila,
Eropkin Mikhail,
Sominina Anna,
Grudinin Mikhail
Publication year - 2016
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12389
Subject(s) - saint petersburg , virology , biology , genome , gene , antigenic drift , influenza season , strain (injury) , flu season , virus , influenza a virus , genetics , influenza vaccine , vaccination , geography , russian federation , anatomy , regional science
A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection ( ARI ) and in number of lethal cases. We performed antigenic analysis of 108 and whole‐genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole‐genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP , E125D in NS 1, M105T in NP , Q208K in M1, and N204S in PA ‐X) that probably emerged before the beginning of 2015/2016 epidemic season.