Open AccessEvaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014
Author(s) -
McAnerney Johanna M.,
Treurnicht Florette,
Walaza Sibongile,
Cohen Adam L.,
Tempia Stefano,
Mtshali Senzo,
Buys Amelia,
Blumberg Lucille,
Cohen Cheryl
Publication year - 2015
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12314
Subject(s) - influenza vaccine , seasonal influenza , virology , strain (injury) , medicine , vaccination , live attenuated influenza vaccine , immunology , covid-19 , disease , infectious disease (medical specialty)
The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test‐negative case–control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI : −26·8–74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.