Open AccessCharacterization of hospital and community‐acquired respiratory syncytial virus in children with severe lower respiratory tract infections in Ho Chi Minh City, Vietnam, 2010
Author(s) -
Tuan Tran Anh,
Thanh Tran Tan,
Hai Nguyen thi Thanh,
Tinh Le Binh Bao,
Kim Le thi Ngoc,
Do Lien Anh Ha,
Chinh B'Krong Nguyen thi Thuy,
Tham Nguyen thi,
Hang Vu thi Ty,
Merson Laura,
Farrar Jeremy,
Thuong Tang Chi,
Jong Menno D.,
Schultsz Constance,
Doorn H Rogier
Publication year - 2015
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12307
Subject(s) - medicine , ho chi minh , respiratory system , pediatrics , respiratory tract , lower respiratory tract infection , respiratory tract infections , virus , virology , socioeconomics , sociology , low income
Background Human respiratory syncytial virus ( RSV ) is an important community and nosocomial pathogen in developed countries but data regarding the importance of RSV in developing countries are relatively scarce. Methods During a 1‐year surveillance study in 2010, we took serial samples from children admitted to the Emergency Unit of the Respiratory Ward of Children's Hospital 1 in Ho Chi Minh City, Vietnam. RSV was detected within 72 hours of admission to the ward in 26% (376/1439; RSV A: n = 320; RSV B: n = 54; and RSV A and B: n = 2). Among those negative in the first 72 hours after admission, 6·6% (25/377) acquired nosocomial RSV infection during hospitalization ( RSV A: n = 22; and RSV B: n = 3). Results Children with nosocomial RSV infection were younger ( P = 0·001) and had a longer duration of hospitalization ( P < 0·001). The rate of incomplete recovery among children with nosocomial RSV infection was significantly higher than among those without ( P < 0·001). Phylogenetic analysis of partial G gene sequences obtained from 79% (316/401) of positive specimens revealed the co‐circulation of multiple genotypes with RSV A NA 1 being predominant (A NA 1: n = 275; A GA 5: n = 5; B BA 3: n = 3; B BA 9: n = 26; and B BA 10: n = 7). The RSV A GA 5 and RSV B BA 3 genotypes have not been reported from Vietnam, previously. Conclusion Besides emphasizing the importance of RSV as a cause of respiratory infection leading to hospitalization in young children and as a nosocomial pathogen, data from this study extend our knowledge on the genetic diversity of RSV circulating in Vietnam.