Open AccessBat cells from P teropus alecto are susceptible to influenza A virus infection and reassortment
Author(s) -
Dlugolenski Daniel,
Jones Les,
Tompkins S. Mark,
Crameri Gary,
Wang LinFa,
Tripp Ralph A.
Publication year - 2013
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12128
Subject(s) - reassortment , biology , influenza a virus , virology , waterfowl , virus , viral replication , microbiology and biotechnology , covid-19 , infectious disease (medical specialty) , ecology , disease , pathology , habitat , medicine
Waterfowl are primary hosts for influenza A viruses ( IAV s); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow‐shouldered bats were shown to be hosts of an IAV , thereby constituting a potential novel reservoir. We show that P teropus alecto kidney cells ( P a K i) are susceptible to infection and sustain replication of A / WSN /33 ( H 1 N 1) and A / V ietnam/1203/04 ( H 5 N 1). Importantly, we show that co‐infection of P a K i cells results in novel reassortants.