Open AccessProgressive emergence of an oseltamivir‐resistant A ( H 3 N 2) virus over two courses of oseltamivir treatment in an immunocompromised paediatric patient
Author(s) -
Hurt Aeron C.,
Leang Sook Kwan,
Tiedemann Karin,
Butler Jeff,
Mechinaud Francoise,
Kelso Anne,
Downie Peter,
Barr Ian G.
Publication year - 2013
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12108
Subject(s) - oseltamivir , neuraminidase , virus , virology , neuraminidase inhibitor , viral shedding , medicine , population , covid-19 , disease , environmental health , infectious disease (medical specialty)
A minor viral population of oseltamivir‐resistant A ( H 3 N 2) viruses ( E 119 V neuraminidase mutation) was selected and maintained in a continually infected immunocompromised child following initial oseltamivir treatment. A subsequent course of oseltamivir given 7 weeks later rapidly selected for the E 119 V variant resulting in a near‐pure population of the resistant virus. The study highlights the challenges of oseltamivir treatment of immunocompromised patients that are continually shedding virus and demonstrates the ability of the E 119 V oseltamivir‐resistant virus to be maintained for prolonged periods even in the absence of drug‐selective pressure.