Open AccessParenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice
Author(s) -
Sanders Robert D.,
Godlee Alexandra,
Goulding John C.,
Ma Daqing,
Maze Mervyn,
Hussell Tracy
Publication year - 2013
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12066
Subject(s) - immunology , pneumonia , immune system , medicine , weight loss , influenza a virus , viral pneumonia , respiratory disease , respiratory system , lung , disease , virus , covid-19 , infectious disease (medical specialty) , obesity
Animal models of viral respiratory disease often use weight loss as a marker of disease severity; however, this may relate to dehydration and malnutrition that would be corrected clinically. We tested whether parenteral fluid therapy improved weight loss from influenza infection. BALB /c and C57 BL /6 mice were infected with A / X 31 ( H 3 N 2) influenza and randomized to intraperitoneal fluid therapy. Blood glucose was also measured post‐viral infection on day 3 and 6 in BALB /c mice and on day 6 in C 57 BL /6 mice. Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal.