Open AccessRetrospective serological survey of influenza viruses in backyard pigs from Mexico City
Author(s) -
SaavedraMontañez Manuel,
CarreraAguirre Víctor,
CastilloJuárez Héctor,
RiveraBenitez Francisco,
RosasEstrada Karina,
PulidoCamarillo Evelyn,
MercadoGarcía Carmen,
CarreónNápoles Rosalba,
HaroTirado Mario,
Rosete Dora P.,
Cabello Carlos,
Manjarrez María E.,
SánchezBetancourt Iván,
RamírezMendoza Humberto
Publication year - 2013
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/irv.12063
Subject(s) - serology , seroprevalence , antigenicity , antibody , titer , virology , hemagglutination assay , antibody titer , antibody response , biology , medicine , virus , immunology
Background In the present study, we analyzed the presence of antibodies to four different influenza viruses ( pH 1N1, hH 1N1, sw H 1 N 1, and sw H 3 N 2) in the sera of 2094 backyard pigs from M exico C ity. The sera were obtained between 2000 and 2009. Objectives The aim of this study was to perform a retrospective analysis of the 2000–2009 period to determine the seroprevalence of antibodies against pH 1N1, hH 1N1, sw H 1 N 1, and sw H 3 N 2 viruses in sera obtained from backyard pigs in M exico C ity. Methods Antibody detection was conducted with hemagglutination inhibition assay ( HI ) using four influenza viruses. We used linear regression to analyze the tendency of antibody serum titers throughout the aforementioned span. Results We observed that the antibody titers for the pH 1 N 1, sw H 1 N 1, and sw H 3 N 2 viruses tended to diminish over the study period, whereas the antibodies to hH 1 N 1 remained at low prevalence for the duration of the years analyzed in this study. A non‐significant correlation ( P > 0·05) between antibody titers for pH 1 N 1 and sw H 1 N 1 viruses was observed (0·04). It contrasts with the significance of the correlation (0·43) observed between the sw H 1 N 1 and sw H 3 N 2 viruses ( P < 0·01). Conclusions Our findings showed no cross‐antigenicity in the antibody response against the same subtype. Antibodies against pH 1 N 1 virus were observed throughout the 10‐year study span, implying that annual strains shared some common features with the pH 1 N 1 virus since 2000, which would then be capable of supporting the ongoing presence of these antibodies.