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Mandibular condyle morphology among patients with mucopolysaccharidosis: An observational study of panoramic radiographs
Author(s) -
SchmidHerrmann Carmen Ulrike,
Muschol Nicole Maria,
Fuhrmann Vera Ulrike,
Koehn Anja Friederike,
Lezius Susanne,
KahlNieke Bärbel,
Koehne Till
Publication year - 2022
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/ipd.12952
Subject(s) - condyle , medicine , radiography , resorption , dentistry , mucopolysaccharidosis i , orthodontics , surgery , enzyme replacement therapy , disease
Background Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption. Aim The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non‐MPS individuals and to describe how condylar changes may vary among the different types of MPS. Design Fifty panoramic radiographs of MPS patients (13.4 ± 6.2 years) with MPS I ( n = 14), MPS II ( n = 2), MPS IV ( n = 8) and MPS VI ( n = 2) were compared with forty panoramic radiographs of non‐MPS individuals. The severity of condylar resorption was evaluated using a qualitative score (grades 0–3) and using the ratio of condylar height to ramus height (CH: RH). Results All MPS I and VI individuals showed pronounced bilateral degenerative condylar resorption. In contrast, individuals with MPS II and IV exhibited heterogeneous findings. The quantification of condylar height to ramus height revealed that CH: RH was significantly decreased in MPS I as compared to that of non‐MPS individuals ( P < .001). In contrast, the CH: RH ratios of MPS II and IV showed great variability. Conclusion Mucopolysaccharidoses subtypes differ with regard to the severity of condylar resorption.