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How researchers should select the best outcomes for randomised clinical trials in paediatric dentistry?
Author(s) -
Mendes Fausto M.,
Braga Mariana M.,
Pássaro Ana Laura,
Moro Bruna L. P.,
Freitas Raiza Dias,
Gimenez Thais,
Tedesco Tamara K.,
Raggio Daniela P.,
Pannuti Claudio M.
Publication year - 2020
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/ipd.12743
Subject(s) - medicine , randomized controlled trial , alternative medicine , clinical trial , outcome (game theory) , medline , evidence based dentistry , clinical practice , paediatric dentistry , population , family medicine , physical therapy , intensive care medicine , dentistry , surgery , mathematics , mathematical economics , pathology , environmental health , political science , law
Randomised clinical trial (RCT) is the best study design to evaluate the effect of the treatment and preventive healthcare procedures. The effects of the tested treatments on patient's health are compared in terms of outcomes, which are used to evaluate the participants' health changes. However, these outcomes should be relevant for the target population. In that way, RCTs represent the type of primary study design that provides the most reliable evidence to implement therapies into the clinical practice. In this review, an outline of some aspects related to the choice of RCTs' outcomes was presented, focusing on the conduction of relevant trials in Paediatric Dentistry. The importance and necessity of defining a primary outcome were addressed, preferentially a clinically relevant endpoint. The patients should perceive this outcome, and changes in this variable should reflect directly patient's health improvement or impairment. Moreover, considerations about the objective or subjective variables, use of surrogate outcomes, and the increasing tendency to develop core outcome sets were also presented in this review. The main idea of this manuscript is the RCTs must evaluate outcomes relevant to the children's oral health in order to contribute to the implementation of treatments in the evidence‐based health practice.