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Alterations in odontogenesis and tooth eruption resulting from exposure to hexavalent chromium in suckling animals
Author(s) -
Sánchez Luciana Marina,
Ubios Ángela Matilde
Publication year - 2020
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/ipd.12573
Subject(s) - medicine , dentistry , potassium dichromate , enamel paint , hexavalent chromium , concomitant , saline , physiology , tooth eruption , zoology , toxicology , chromium , molar , biology , chemistry , inorganic chemistry , organic chemistry
Background Heavy metals including Cr VI are present in inadequately treated effluents that contaminate drinking water. Hence, Cr VI exposure can affect children through intake of breast milk from an exposed mother or bottle‐feeding formula prepared with contaminated water. To date, there are no reports on the effects of Cr VI exposure on tooth formation processes concomitant to tooth eruption. Aim To study the effect of Cr VI exposure on tooth tissue formation in suckling Wistar rats by assessing dental tissues at different stages of tooth eruption. Design Experimental animals received 12.5 mg/kg body weight/day of a potassium dichromate solution by gavage; control animals were similarly administered an equivalent volume of saline solution. Each group was divided into three subsets according to age at euthanasia: 9, 15, and 23 days. Dental formation was analysed histologically and histomorphometrically. Statistical analysis: Student's t test; P < .05. Results Cr VI‐exposed animals showed a delay in mineralized crown and root tissue formation. These findings are directly associated with the observed delay in tooth eruption. Conclusion Our findings show the importance of monitoring drinking water levels of toxic substances, since exposure during early childhood can alter tooth formation, growth, and development.