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Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study
Author(s) -
Teixeira Rafael José Pio Barbosa,
Andrade Natália Silva,
Queiroz Lisanca Carvalho Cavalcante,
Mendes Fausto Medeiros,
Moura Marcoeli Silva,
Moura Lúcia de Fátima Almeida de Deus,
Lima Marina Deus Moura
Publication year - 2018
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/ipd.12327
Subject(s) - medicine , concordance , etiology , twin study , dizygotic twin , confidence interval , dizygotic twins , pregnancy , obstetrics , dentistry , heritability , genetics , biology
Background The etiology of molar‐incisor hypomineralization (MIH) remains unknown. Studies indicate that it is multifactorial, and that genetic and environmental factors are involved. Research with twins provides important subsidy to investigate the Influence of genetics and environmental factors that act during pregnancy on the etiology of alterations. Aim This cross‐sectional study evaluated the agreement of molar incisor hypomineralization ( MIH ) between monozygotic and dizygotic twin pairs and the association with environmental factors. Design The sample consisted of 167 pairs of twins (8–15 years old), 94 monozygotic and 73 dizygotic. The parents answered a questionnaire on sociodemographic data and pre‐, peri‐, and postnatal health. A dental examination was performed by two calibrated examiners (Kappa ≥0.88) for MIH diagnosis, following the criteria proposed by the European Academy of Pediatric Dentistry in 2003. Results The prevalence of MIH was 29.3%. There was greater concordance of MIH between monozygotic twins for affected first molars and permanent incisors ( P = 0.0012) and pairs of twins assessed ( P = 0.0211). The presence of MIH was associated with family income between one and two wages ( P = 0.009, prevalence ratio [ PR ] = 3.82, confidence interval [ CI 95%] 1.40–10.44), above two wages ( P = 0.007, PR = 4.60, 95% CI : 1.51–14.05), and gestational hemorrhage ( P = 0.032, PR = 5.70, 95% CI : 1.16–28.14). Conclusions The greater concordance in the diagnosis of MIH among monozygotic twins indicates a genetic influence, although environmental factors, such as family income and hemorrhage during pregnancy, are also associated with the occurrence of MIH .