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Urinary fluoride excretion after application of fluoride varnish and use of fluoride toothpaste in young children
Author(s) -
Lockner Frida,
Twetman Svante,
StecksénBlicks Christina
Publication year - 2017
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1111/ipd.12284
Subject(s) - fluoride , toothpaste , fluoride varnish , medicine , dentistry , varnish , excretion , chemistry , inorganic chemistry , organic chemistry , coating
Background The efficacy and safety of combined use of topical fluoride products are essential issues that must be monitored. Aim To assess urinary excretion of fluoride after application of two different dental varnishes containing 2.26% fluoride in 3‐ to 4‐year‐old children and to compare the levels with and without parallel use of fluoride toothpaste. Design Fifteen healthy children were enrolled to a randomized crossover trial that was performed in two parts: Part I with twice‐daily tooth brushing with fluoride toothpaste and Part II with twice‐daily brushing with a non‐fluoride toothpaste. After a 1‐week run‐in period, 0.1 mL of the two fluoride varnishes (Duraphat and Profluorid Varnish) was topically applied in a randomized order. Baseline and experimental urine was collected during 6‐h periods. The fluoride content was determined with an ion‐sensitive electrode. Results There was a statistically significant increase in the 6‐h fluoride excretion after application of both experimental varnishes, with and without parallel use of fluoride toothpaste ( P < 0.01). When fluoridated toothpaste was used, the mean fluoride excretion was 0.20 mg/6 h after application of Duraphat and 0.29 mg/6 h after application of Profluorid Varnish ( P = 0.18). Conclusions Topical applications of 0.1 mL of fluoride varnish significantly increased the 6‐h fluoride excretion. As some individuals displayed excretion levels exceeding the optimal fluoride exposure, a restricted use of fluoride toothpaste in connection with the varnish applications would decrease fluoride exposure.