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Indoor microbiome and risk of lower respiratory tract infections among children under‐five years: A meta‐analysis
Author(s) -
Fakunle Adekunle G.,
Jafta Nkosana,
Okekunle Akinkunmi P.,
Naidoo Rajen N.
Publication year - 2020
Publication title -
indoor air
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.387
H-Index - 99
eISSN - 1600-0668
pISSN - 0905-6947
DOI - 10.1111/ina.12698
Subject(s) - meta analysis , cochrane library , odds ratio , medicine , confidence interval , respiratory tract infections , relative risk , publication bias , medline , microbiome , environmental health , respiratory system , bioinformatics , biology , biochemistry
We investigated whether exposure to microbiome within the indoor environment is associated with risk of lower respiratory tract infections (LRTI) among children under 5 years of age. Electronic scientific repositories; PubMed, Scopus, Web of Science, GreenFILE, EMBASE, and Cochrane library were searched and screened through July 2019 for published reports for inclusion in the meta‐analysis. Studies were eligible for inclusion if they reported an adjusted measure of risk for LRTI associated with IM exposure, including the relative risk (RR) or odds ratio (OR) and confidence interval (CI). The pooled OR was computed using the inverse of variance method for weighting. Sensitivity analysis was used to evaluate the effect of individual studies, while heterogeneity was evaluated by I 2 statistics using RevMan 5.3. Seven studies were eligible for inclusion in our meta‐analysis. Exposure to a higher concentration of IM was associated with an increased risk of LRTI [OR:1.20 (1.11, 1.33), P < .0001]. The risk was stronger with exposure to total fungal concentration [OR:1.27 (1.13, 1.44), P < .0001] than visible molds [OR:1.20 (1.07, 1.34, P = .001]. Under‐five children exposed to higher IM concentration are likely at increased risk of LRTI. Interventions addressing IM exposure should be considered in the management of LRTI among under‐five children.