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Exposure to organophosphate and polybrominated diphenyl ether flame retardants via indoor dust and childhood asthma
Author(s) -
Canbaz D.,
Velzen M. J. M.,
Hallner E.,
Zwinderman A. H.,
Wickman M.,
Leonards P. E. G.,
Ree R.,
Rijt L. S.
Publication year - 2016
Publication title -
indoor air
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.387
H-Index - 99
eISSN - 1600-0668
pISSN - 0905-6947
DOI - 10.1111/ina.12221
Subject(s) - polybrominated diphenyl ethers , organophosphate , asthma , diphenyl ether , inhalation exposure , environmental health , environmental chemistry , inhalation , medicine , chemistry , pesticide , pollutant , biology , organic chemistry , anesthesia , agronomy
Although the ubiquitous detection of polybrominated diphenyl ether ( PBDE ) and organophosphate flame retardants ( PFR s) in indoor dust has raised health concerns, only very few epidemiological studies have assessed their impact on human health. Inhalation of dust is one of the exposure routes of FR s, especially in children and can be hazardous for the respiratory health. Moreover, PFR s are structurally similar to organophosphate pesticides, which have been associated with allergic asthma. Thus, we investigated whether the concentrations of PFR s and PBDE s in indoor dust are associated with the development of childhood asthma. We selected 110 children who developed asthma at 4 or at 8 years old and 110 matched controls from a large prospective birth cohort ( BAMSE – Barn, Allergy, Milieu Stockholm Epidemiology). We analyzed the concentrations of 7 PFR s and 21 PBDE s in dust collected around 2 months after birth from the mother's mattress. The abundance rank in dust was as follows: TBOEP ⪢ TPHP >mmp‐ TMPP > EHDPHP ~ TDCIPP > TCEP ~ TCIPP ~ BDE ‐209⪢ BDE ‐99> BDE ‐47> BDE ‐153> BDE ‐183> BDE ‐100. There was no positive association between the FR s in mattress dust and the development of childhood asthma. In contrast, dust collected from mattresses of the mothers of children who would develop asthma contained significant lower levels of TPHP and mmp‐ TMPP . This study provides data on a wide range of PFR s and PBDE s in dust samples and development of asthma in children.