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Cancer‐associated fibroblasts: Key players in shaping the tumor immune microenvironment
Author(s) -
Desbois Mélanie,
Wang Yulei
Publication year - 2021
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12982
Subject(s) - tumor microenvironment , cancer associated fibroblasts , immune system , context (archaeology) , cancer , immunotherapy , biology , cancer immunotherapy , immunology , cancer research , paleontology , genetics
Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer. Nevertheless, most of the patients show innate or acquired resistance to these therapies. Studies conducted in recent years have highlighted an emerging role of cancer‐associated fibroblasts (CAFs) in immune regulation that shapes the tumor immune microenvironment (TIME) and influences response to cancer immunotherapies. In this review, we outline recent advances in the understanding of phenotypic and functional heterogeneity of CAFs. We will focus on emerging roles of CAFs in shaping the TIME, especially under a framework of tumor immunity continuum, and discuss current and future CAF‐targeting therapeutic strategies in particular in the context of optimizing the success of immunotherapies.