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The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity
Author(s) -
Ovsyannikova Inna G.,
Haralambieva Iana H.,
Crooke Stephen N.,
Poland Gregory A.,
Kennedy Richard B.
Publication year - 2020
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12897
Subject(s) - covid-19 , biology , immune system , coronavirus , disease , human leukocyte antigen , host response , genetics , virology , immunology , infectious disease (medical specialty) , medicine , antigen , pathology , outbreak
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus‐mediated disease. The initial sections focus on seasonal coronaviruses, SARS‐CoV, and MERS‐CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS‐CoV‐2 and COVID‐19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS‐CoV‐2.