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Complement and human T cell metabolism: Location, location, location
Author(s) -
West Erin E.,
Kunz Natalia,
Kemper Claudia
Publication year - 2020
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12852
Subject(s) - complement (music) , biology , complement system , cell metabolism , immune system , classical complement pathway , innate immune system , computational biology , alternative complement pathway , complement receptor , cell , immunology , microbiology and biotechnology , genetics , gene , phenotype , complementation
The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver‐derived and serum‐active system critical for providing protection against invading pathogens. Recent unexpected findings, however, have defined novel and rather “uncommon” locations and activities of complement. Specifically, the discovery of an intracellularly active complement system—the complosome—and its key role in the regulation of cell metabolic pathways that underly normal human T cell responses have taught us that there is still much to be discovered about this system. Here, we summarize the current knowledge about the emerging functions of the complosome in T cell metabolism. We further place complosome activities among the non‐canonical roles of other intracellular innate danger sensing systems and argue that a “location‐centric” view of complement evolution could logically justify its close connection with the regulation of basic cell physiology.